Differential scanning calorimetry and NMR study of water confined in a mesoporous bioactive glass

The emergence of a new generation nanostructured materials opened wide range potential applications for Bioglasses such as DNA vaccination, cellular treatment or drug delivery with well-controlled loading and release (bio)active molecules. In this study we compare structural, dynamic thermal properties water confined in two CaO–SiO2–P2O5 mesoporous bioactive glasses (MBGs). One the MBGs is prepared by standard sol-gel methods other microfluidic procedures, therefore both have same molar compositions (92% SiO2, 6% CaO, 2% P2O5) but different textural (surface areas, porous volume grain architecture). These are intended to interact body fluids which essentially composed water, it crucial understand water-MBG interaction. With objective, apply complementary approach based on 1H field-cycling NMR relaxometry, magic-angle spinning spectroscopy differential scanning calorimetry (DSC). low-field relaxometry observe that adsorbed has behavior channels systems, escaping molecules towards bulk slightly faster material. By combining MAS DSC series MBG samples at variable temperature content, low pooling less pronounced case MBG. All our results point microcapsule organization provides better access full volume.